Exfoliated FePS3 nanosheets for T1-weighted magnetic resonance imaging-guided near-infrared photothermal therapy in vivo

Developing bifunctional nanoplatforms integrating advanced biological imaging with high-performance therapeutic functions is interesting for nanoscience and biomedicine. Herein, thin-layered FePS3 nanosheets modified amine polyethylene glycol (FePS3-PEG) are synthesized by ultrasonicated exfoliation of bulk single crystals under Ar atmosphere in situ chemical functionalization PEG. The prepared FePS3-PEG give a photothermal conversion efficiency 22.1% 808-nm laser evident T1 relaxation (r1 = 2.69 (mmol L?1)?1 S?1) external magnetic fields. Biologically experimental results vitro vivo demonstrate that have good biocompatibility exhibit excellent therapy (PTT) effect clear weighted resonance (MRI). characteristics enable them to be promising nanomedicine T1-weighted MRI-guided near-infrared PTT cancers.